π-Alpha™ 293 AAV 高収量生産プラットフォーム

主な利点

Performance

• Enhanced Productivity and Scalability

  The PCS3.0 suspension cell line, combined with a uniquely engineered RC plasmid, enhances AAV production efficiency. This optimized system enables greater scalability for large-scale manufacturing.

  

  Fig 1. PackGene’s proprietary RC plasmid significantly increases AAV production yield

   

  

  Fig 2. PCS3.0 cell line performance in ssAAV9 AAV production

   

  

  Fig 3. π-Alpha 293 AAV high-yield platform achieves scalable production

• Superior Purity

  The optimized production process not only increases AAV yields but also significantly reduces the impurities.

   

  

  Fig 4. Process optimization significantly minimizes encapsidated plasmid DNA

  

  Fig 5. Substantial reduction of residual HCD via process optimization

• Improved safety and bioactivity

  The PackGene’s RC plasmid enhances full/empty capsid ratio to improve safety and bioactivity.

   

  

  Fig 6. High full capsid rate through process optimization (UC>98%, AEX>90%）

  

  Fig 7. PackGene’s RC plasmid significantly increases high full/empty capsid ratio.

リソース

• PackGene’s new GMP AAV manufacturing site-Houston, TX