AAVライブラリー

主な利点

サービスの詳細

• Diverse Library Designs

  

• More library design we can handle

  

パフォーマンス

• Library quality

  Near 100% coverage of our precision library

  Excellent library uniformity

• Low mispackaging rates

  
  Mismatched capsid versus genome can be assessed by introducing a low frequency of capsid genes with early stop codons. The frequency of these stop codons indicates the mismatched rate. Typically, we achieve a mispackaging rate of less than 0.1% using our special AAV library packaging protocol, ensuring that NGS of the enriched capsid gene in the targeted tissue accurately represents the capsids specifically targeting that tissue.

• Screening result

  Final validation of novel muscle targeting Capsid screened in Cynomolgus Monkey
  

リソース

• Generation of novel AAV serotype with enhanced infectivity, specificity, and lower toxicity via π-Icosa AAV Capsid Engineering platform

• Capsid Engineering Application Note