HBV Hepatitis B modeling-rAAV
Features of HBV rAAV Vector
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Highest Security
Compared with Lentivirus and Adenovirus, rAAV shows outstanding safety advantages including an low probability of genome integration, low immunogenicity, and high experimental operation safety. -
Long-term Transduction
Over the past 20 years, rAAV has been commonly used as a tool for efficient and long-term gene expression in basic research and clinical gene therapy. For example, rAAV induced transgene expression in non-human primate muscle tissue can last for more than 10 years. -
Organ Specificity
The capsid proteins of different AAV serotypes recognize different receptors on the cell surface, cell infection efficiency varies across tissues, indicating organ targeting specificity. AAV8 is frequently used in liver research and is therefore the serotype of choice for generation of the AAV-HBV mouse model.
Our Advantages
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Low Empty Shell
AAV-HBV TEM detects empty shell rate is below 30% -
Low Endotoxin
Low endotoxin levels with <10EU/ml – suitable for animal experiments. -
AAV-HBV Mycoplasma Test Negative
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High Purity Titer
≥1E+13GC/ml for AAV8-based qPCR genome copies/ml -
Complete Quality Inspection Reports Are Provided
Products Details
| Catalog No. | Promoter type | Genotype and serotype |
|---|---|---|
| AAV-D#2012 | ssAAV-HBV-D,ayw | HBV-D, serotype ayw (The AAV virus harbors the l.3XHBV genome, belonging to genotype D and serotype ayw. This strain is capable of generating HBV DNA, HBeAg, and HBsAg. Originally employed in cell models and transgenic animals, it has become extensively utilized in contemporary HBV research. It is suitable for both cell and animal experiments.) |
| AAV-C-10433 | ssAAV-HBV-C,adr | HBV-C, serotype adr (The AAV virus carries the 1.3XHBV genome, belonging to genotype C2 and serotype adr. It can produce HBV DNA, HBeAg, and HBsAg. The C-type HBV is a prevalent strain, known for its strong pathogenicity, although its mechanism remains unclear. It should be given careful consideration in drug development. Suitable for both cell and animal experiments.) |
| AAV-C-542 | ssAAV-HBV-B, adw | HBV-B, serotype adw (The AAV virus harbors the 1.3XHBV genome, characterized by genotype B and serotype adw. It has the ability to produce HBV DNA, HBeAg, and HBsAg. Although the B-type HBV is also common, its pathogenicity is comparatively weaker than that of the C-type. However, it still warrants attention in drug development. Suitable for both cell and animal experiments.) |
Notice
50ul and 100ul specification are available.
Technical Details
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Operation Requirements
In 1994, the safety of rAAV as a gene therapy vector was recognized by the FDA. AAV are classified as biological safety is Grade 1 (BSL-1), which is the same as that of plasmid DNA. It is nevertheless recommended to adhere to BSL-2 laboratory precautions with a ClassⅡ biological safety cabinet for use.
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Storage Requirements
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Designing AAV-HBV Mouse Model