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Targeted genome editing of ZKSCAN3 mitigates the neurotoxicity caused by mutant HTT (huntingtin) in a Huntington disease animal model and three-dimensional cell culture of Huntington disease
Author:
Hyun Jung Park, JiYeon Kim, Jiwoo Choi, Chongsuk Ryou, Eunji Shin & Jae Young Lee
Journal: Autophagy
Doi: https://www.doi.org/10.1080/15548627.2025.2569965
2025/10/10 -
Ototoxicity-induced c-Fos activation underlies the regenerative capacity of the vestibular sensory epithelia
Author:
Yunzhong Zhang, Dan You, Chenhao Che, Xinyuan Wang, Huawei Li, Yi-Quan Tang, Shan Sun
Journal: Cell Communication and Signaling
Doi: https://www.doi.org/10.1186/s12964-025-02446-y
2025/10/8 -
HnRNP M expression rescues neurodegeneration in neuronal intranuclear inclusion disease mouse model by restoring dysregulated RNA splicing and transcription
Author:
Yongcheng Pan, Yangping Li, Ying Jiang, Xinhui Wang, Juan Wan, Qiying Sun, Yun Tian, Lu Shen, Hong Jiang, Beisha Tang, Bing Yao, Qiong Liu
Journal: Cell and Bioscience
Doi: https://www.doi.org/10.1186/s13578-025-01477-9
2025/10/6 -
AAV-mediated allele-specific silencing alleviates neuropathology in a novel non-human primate model of Spinocerebellar ataxia type 3
Author:
Carina Henriques, Diana Duarte Lobo, Ana Carolina Silva, Ana Rita Fernandes, Miguel Monteiro Lopes, Audrey Fayard, Caroline Jan, Sophie Lecourtois, Martine Guillermier, Julien Flament, João Castelhano, Miguel Castelo-Branco, Rui Caetano Oliveira, Philippe Hantraye, Padmaja Yalamanchili, Steven de Marco, Romina Aron Badin, Luís Pereira de Almeida and Rui Jorge Nobre
Journal: BioRxiv
Doi: https://www.doi.org/10.1101/2025.10.02.680027
2025/10/2 -
rAAV-Delivered Bicistronic Artificial microRNAs for Allele-Specific Silencing Improve Motor and Molecular Outcomes in Spinocerebellar Ataxia Type 3
Author:
Ana Carolina Silva, Carina Henriques, Diana D. Lobo, Ana Rita Fernandes, Miguel M. Lopes, Kevin Leandro, Dina Pereira, Sónia P. Duarte, Sara M. Lopes, Magda M. Santana, Amal Dakka, Steve De Marco, Marla Weetall, Jana Narasimhan, Anu Bhattacharyya, Rui Jorge Nobre and Luís Pereira de Almeida
Journal: BioRxiv
Doi: https://www.doi.org/10.1101/2025.10.02.680011
2025/10/2 -
Detecting MUNC18-1 related presynaptic dysfunction and rescue in human iPSC-derived neurons
Author:
Manzhao Long, Jennifer Zoll, Sharanya Unnikrishnan, Edward Guilmette, Davide Gianni, Sijia Wu, Christopher A Hinckley
Journal: Sci Rep
Doi: https://www.doi.org/10.1038/s41598-025-11059-x
2025/9/30 -
A CpG 1018S/QS-21-Adjuvanted HBsAg Therapeutic Vaccine as a Novel Strategy Against HBV
Author:
Zixuan Wang, Jing Wu, Xiaohan Meng, He Weng, Qiang Li, Lin Li, Zhenhao Ma, Sirong Bi, Qiuju Han, Huajun Zhao, Cunbao Liu and Deping Meng
Journal: Vaccines
Doi: https://www.doi.org/10.3390/vaccines13101014
2025/9/29 -
A non-apoptotic caspase-8–meteorin pathway in hepatocytes promotes MASH fibrosis
Author:
Xiaobo Wang, Mary P. Moore, Hongxue Shi, Yang Xiao, Jiayu Zhang, Lanuza A. P. Faccioli, Zhiping Hu, Shareef Khalid, Danish Saleheen, Dwayne G. Stupack, Tatiana Kisseleva, Alejandro Soto Gutierrez, Mitchell A. Lazar & Ira Tabas
Journal: Nature Metabolism
Doi: https://www.doi.org/10.1038/s42255-025-01355-1
2025/9/26 -
A two-strata energy flux system driven by a stress hormone prioritizes cardiac energetics
Author:
Zhiheng Rao, Zhichao Chen, Yuxuan Bao, Zhenzhen Lu, Yuli Tang, Jiamei Zhu, Jianjia Ma, Siyang Dong, Jiawei Shi, Suhui Sheng, Yajing Chen, Jiaojiao Wang, Alan Vengai Mukondiwa, Ziyue Li, Xulan Wang, Zibo Huang, Chi Li, Wumengwei Ding, Mengjie Chen, Ziyi Han, Cong Wang, Xuebo Pan, Xiaojie Wang, Hong Zhu, Li Lin, Zhifeng Huang, Weiqin Lu, Xiaokun Li, Yongde Luo
Journal: Signal Transduct Target Ther
Doi: https://www.doi.org/10.1038/s41392-025-02402-9
2025/9/26 -
Astragaloside IV reduces hepatitis B surface antigen level via monocyte/macrophages in chronic HBV infection mice
Author:
Mengling Jiang, Meifang Tang, Lifen Zhu, Pei Zhou, Haiyi Cai, Qinghong Fan, Xiaoqian Wang, Yaping Wang, Jianming Liang, Feng Li, Xinghua Tan
Journal: Phytomedicine
Doi: https://www.doi.org/10.1016/j.phymed.2025.157308
2025/9/24 -
Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model
Author:
Zhaoyichun Zhang, Yanran Zhang, Jialin Si, Honghui Mao, Feng He, Jin Ning, Guaiguai Ma, Xiaohua Chen, Haoxiang Xiao, Yuanyuan Zhu, Haifeng Zhang, Yifan Lu, Qian Liu, Meng Nian, Shiquan Sun, Shibin Yu, Shengxi Wu, Ze Fan, Zuolin Jin, Jing Huang
Journal: Advanced Science
Doi: https://www.doi.org/10.1002/advs.202509509
2025/9/24 -
Screening of Single-Domain Antibodies to Adeno-Associated Viruses with Cross-Serotype Specificity and a Wide pH Tolerance
Author:
Hailing Guo, Shuo Wang, Lujin Feng, Weiwei Xu, Jiandong Zhang, Xiaoju Zhou and Ningning Ma
Journal: Viruses
Doi: https://www.doi.org/10.3390/v17101289
2025/9/23